|
|
|
|
|
Click Here to return To Results
|
|
|
|
Chronic lymphocytic leukemia is the most common human leukemia but infrequently causes neurologic symptoms.We have reviewed all previously reported cases of chronic lymphocytic leukemia in the CNS along with three new cases;one patient was diagnosed antemortem and treated with immediate improvement and 4-year survival.In addition,we reviewed all autopsy cases since 1972 and available lumbar puncture data on patients with chronic lymphocytic leukemia admitted to the Massachusetts General hospital. Invasion of the CNS by chronic lymphocytic leukemia often leads to confusional state,meningitis with cranial nerve abnormalities,optic neuropathy,or cerebellar dysfunction.Lumbar puncture shows a lymphocytosis consisting of monoclonal B cells,but CSF cytology studies are of limited value in establishing the diagnosis.Long-term survival may be related to the stage of chronic lymphocytic leukemia at the time of CNS disease and may be associated with intrathecal chemotherapy.A mild,asymptomatic infiltration of the brain,frequently noted in late-stage chronic lymphocytic leukemia in autopsy series,may explain the CSF lymphocytosis in some patients with late-stage chronic lymphocytic leukemia. |
|
(click to filter results - removes previous filter)
ataxia
ataxia,cerebellar
cerebrospinal fluid
cerebrospinal fluid,abnormal
cerebrospinal fluid,cytology
cerebrospinal fluid,cytology,false negative
confusion
cranial nerve palsies
cranial neuropathy
cranial neuropathy,multiple
fever
gliomatosis cerebri
headache
intrathecal chemotherapy
leukemia
leukemia,neurologic findings assoc.with
meningitis
mononeuropathy
neuropathology
optic neuropathy
pleocytosis of cerebrospinal fluid
prognosis
review article
treatment of neurologic disorder
|
Click Here to return To Results
|
|